Charles Brenton Huggins, M.D.
(September 22, 1901 - January 12, 1997)

"Research has always been my pleasure as well as my job.
There is nothing that matches the thrill of discovery"

In 1927 Charles Huggins accepted the invitation of Dallas B. Phemister, founding Chairman of the Department of Surgery, to join the faculty of the University of Chicago School of Medicine instead of entering the private practice of surgery in Kalamazoo, Michigan. It was a fateful decision not only for Huggins, but also for the University. Charles Huggins, not quite 26 years old, became one of the original eight faculty members of the medical school. He had graduated from Harvard Medical School and had just completed advanced training in surgery at the University of Michigan under another great American surgeon, Frederick A. Coller. He was also recently married to his beloved Margaret Wellman. Few could have predicted that Huggins would become one of the giants of the Chicago medical faculty, serving his University at the laboratory bench each day for more that 60 years. During these extraordinarily fruitful and exciting years, he became the leading urologist of his day as well as a world-renowned scientist. His research on prostate cancer brought hope to the prospect of treating advanced cancers. By showing that cancer cells were dependent on chemical signals such as hormones to grow and survive, and that depriving the cancer cells of those signals could restore health to patients with widespread metastases, Dr. Huggins provided an immense stimulus to research on cancer chemotherapy. He proceeded to adapt his research to the study of breast cancer His body of research earned him the Nobel Prize in 1966 for the discovery of new principals for the treatment of advanced cancers. He founded the world-renowned cancer research laboratory, The Ben May Laboratory for Cancer Research at the University of Chicago, and he trained and inspired numerous prominent medical scientists. Most importantly, Charlie was a friend to all, an inspiring teacher and a true role model for all of us.

(adapted from: Remembering the University of Chicago, The University of Chicago Press, 1991)

SCHEDULE OF EVENTS

7:00 CONTINENTAL BREAKFAST AND POSTER SET-UP

"A" Corridor

(West of Dean’s Office)

8:00 INTRODUCTION P-117

Bruce L. Gewertz, M.D.

The Dallas B. Phemister Professor and Chairman,

Department of Surgery

8:10 SESSION I      (P-117)

Moderator:

Hisham S. Bassiouny, M.D.
Professor
Department of Surgery,
Section of Vascular Surgery

10:15 POSTER VIEWING AND COFFEE BREAK         "A" Corridor (West of Dean’s Office)

11:00 SESSION II   (P-117)

Moderator:

Jai Raman, M.D., Ph.D.
Associate Professor
Department of Surgery
Section of Cardiac and Thoracic Surgery

1:00 LUNCHEON AND AWARDS PRESENTATION   (P-211)

SESSION I

Moderator:

Hisham S. Bassiouny, M.D.
Professor, Department of Surgery
Section of Vascular Surgery

BMP14 GENE THERAPY EFFECTIVELY INCREASES TENDON TENSILE STRENGHT IN A RAT MODEL OF ACHILLES TENDON INJURY. Patrick Bolt, Neil Clerk, Hue Luu, Quan Kang, Tong-Chuan He, Rex Haydon, Brian Toolan.

A 20-YEAR EXPERIENCE WITH TOXIC EPIDERMAL NECROLYSIS SYNDROME: A NON-SHEAR TREATMENT APPROACH IN A UNIVERSITY BURN CENTER. Amir Dorafshar, Sara Dickie, Joyce Aycock, Mark Villa, Alvin Cohn, Lawrence Gottlieb.

SINUSOIDAL ENDOTHELIAL APOPTOSIS IS ASSOCIATED WITH REDUCTION OF CIAP-1 FOLLOWING COLD HYPOXIA/WARM REOXYGENATION IN VITRO. Jessica Harman, Kimberly Brown, David R. Holt, Richard L. Gamelli, John J. Brems, Anita S. Chong, Jin Wen Ding

SOS: A SIMPLIFIED SYSTEM FOR SELECTING OPTIMAL siRNA TARGET SITES FOR RNAi-MEDIATED GENEN SPLICING. Chris Song, Qing Luo, Quan Kang, Hue H. Luu, Xiaoji Luo, Wei Jiang, Hong Yin, Hanli Fan, Rex C. Haydon, and Tong-Chuan He*.

THE LONGEVITY FACTOR SIR2á DEACETYLASE PROTECTS CARDIAC MYOCYTES FROM ANGIOTENSIN-II MEDIATED HYPERTROPHY AND CELL-DEATH. Mahesh P. Gupta, Jyothish B. Pillai , Ayman Isbatan, Jai Raman, Valluvan Jeevanandam.

RADICAL CYSTECTOMY IN THE ELDERLY. Frederick P. Mendiola, Albert A. Mikhail, Marcelo A. Orvieto, Lamda P. Msezane, Benjamin R. Stockton, Kevin Zorn, Gary Steinberg.

THE USE OF THE RED WINE DERIVATIVE RESVERATROL AS AN ADJUNCT IN TNF-á BASED ADENOVIRAL GENE THERAPY. Kai Bickenbach, Jula Veerapong, Ralph Weichselbaum, Mitchell Posner*.

TREATMENT OF POLYETHYLENE-INDUCED OSTEOLYSIS USING OSTEOGENIC BMPS IN A MOUSE MODEL OF OSTEOLYSIS. David Manning, Hue H. Luu, Quan Kang, Tong-Chuan He, and Rex C. Haydon.

POSTER SESSION

1. VAC (VACUUM ASSISTED CLOSURE) DRESSING CHANGE PAIN ASSESSMENT USING TOPICAL LIDOCAINE VS. PLACEBO: A DOUBLE BLIND, PROSPECTIVE, RANDOMIZED STUDY. Jayant Agarwal, Robert Lohman, Mietka Franczyk, and Lawrence Gottlieb*.

2. A NOVEL BIMODAL APPROACH TO LARGE TUMORS OF THE ORO- AND NASOPHARYNGEAL SPACE. Mihir K. Bhayani, Farhad Sigari, Kerstin Stenson*.

3. TUMOR NECROSIS FACTOR-á BASED ADENOVIRAL GENE THERAPY AS A POTENTIAL STRATEGY TO DOWNSTAGE LOCALLY ADVANCED CHOLANGIOCARCINOMA. Kai Bickenbach, Jula Veerapong, Hank Schmidt, Ralph Weichselbaum, Kevin Roggin*.

4. A RADIOGRAPHIC COMPARISON OF TWO FLATFOOT RECONSTRUCTION PROCEDURES. Patrick Bolt, Samuel Coy, Brian Toolan*.

5. EFFECT OF LOW SHEAR STRESS AND BALLOON INJURY IN ARTERIAL REMODELING. Amito Chandiwal, James Vosicky, Ralph Weichselbaum, Lewis Schwartz, Christopher Skelly*.

6. EPIDERMAL OVERGRAFTING IMPROVES COLORATION IN GRAFTS AND FLAPS. Alvin B.Cohn, Elisabeth K. Beahm, Robert L. Walton*

7. DEFINITIVE CLOSURE OF THE INFECTED MEDIAN STERNOTOMY WOUND: A TREATMENT ALGORITHM UTILIZING VACUUM ASSITED CLOSURE DEVICE FOLLOWED BY RIGID PLATE FIXATION. Sara Dickie, Amir Dorafshar, David Song*.

8. LAPAROSCOPIC RADICAL NEPHRECTOMY: COMPARISON OF CLINICAL T1 AND T2 RENAL TUMORS. Edward M. Gong, Marcello Orvieto, Alvaro Lucioni, Glenn S. Gerber, Arieh L. Shalhav*.

9. COMPARISON OF LAPAROSCOPIC AND OPEN PARTIAL NEPHRECTOMY: THE UNIVERSITY OF CHICAGO EXPERIENCE. Edward M Gong, Marcelo A Orvieto, Frederick P Mendiola, Gary D Steinberg, Arieh L Shalhav*

10. A NOVEL APPROACH IN THE TREATMENT OF RADIORESISTANT PANCREATIC CANCER: THE ROLE OF INTERFERON GAMMA (IFNã) AND TUMOR NECROSIS FACTOR ALPHA (TNFá). Mukta Katdare, Elena Efimova, Michael Garafolo, Thomas Darga, Ralph Weichselbaum, Mitchell Posner*.

11. INHIBITION OF NUCLEAR FACTOR KAPPA B (NFêB) BY SELECTIVELY SUPPRESSING THE INHIBITOR OF êB KINASE (IKK) SENSITIZES HUMAN TUMOR CELLS TO TUMOR NECROSIS FACTOR ALPHA (TNF á) INDUCED APOPTOSIS. Mukta Katdare, Elena Efimova, Michael Garafolo, Thomas Darga, Ralph Weichselbaum, Mitchell Posner*.

12. SECONDARY INTERVENTIONS FOR EVAR COMPLICATION: LESSONS LEARNED. Erika R. Ketteler, Hisham S. Bassiouny, James F. McKinsey, Lewis B. Schwartz, Brian Funaki, Margaret L. Schwarze, Victor Bernhard, Bruce L. Gewertz, Tina R. Desai*.

13. THE SAFETY AND EFFICACY OF RETRIEVABLE VENA CAVA FILTERS IN A HIGH-RISK SURGERY POPULATION. Giancarlo Piano*, Erika R. Ketteler, Vivek Prachand, Thuong G. Van Ha, Bruce L. Gewertz, John C. Alverdy.

14. TEMPORAL AUGMENTATION OF FLEXOR TENDON HEALING MEDIATED BY BMP13 IN A RABBIT MODEL. Jennifer Kummer, Hendrik Kirchhoff, Kirstina Olson, Andre Spiguel, Hue H. Luu, Tong-Chuan He, Rex C. Haydon, and Daniel P. Mass*.

15. THE UTILITY OF LIP BIOPSY IN THE DIAGNOSIS AND TREATMENT OF SJOREN’S SYNDROME. Alexander Langerman, Elizabeth Blair*, Nadera Sweiss, Jerome Taxy*.

16. AN INDIRECT ROLE FOR THE SPLEEN IN FUNCTIONAL ISLET BETA-CELL REGENERATION. David D. Lee, Dengping Yin, Jing Tao, Jikun Shen, Manami Hara, James Lopez, Andrey Kuznetsov, Louis H. Philipson and Anita S. Chong*.

17. PERIPHERAL DELETION OF ALLO-REACTIVE B CELLS INDUCED BY COSTIMULATION BLOCKADE. Yijin Li, Lianli Ma, Jikun Shen, Roberta Pelanda, Anita Chong.

18. REGULATION OF CELL DEATH IN ISCHEMIA-REPERFUSION: ROLE OF MITOCHONDRIAL OXIDANT STRESS AND MITOCHONDRIAL DNA DAMAGE. Gabriel Loor, Paul Schumacker, Bruce Gewertz*.

19. INITIAL EVALUATION OF THE EFFECT OF INJECTION VOLUMES OF INTRAVESICAL BOTULINUM-A TOXIN INJECTIONS IN PATIENTS WITH OVERACTIVE BLADDER SYMPTOMS. Alvaro Lucioni, David Rapp, Edward Gong, Paula Fedunok, Gregory Bales*.

20. BOTULINUM TOXIN TYPE A INHIBITS SENSORY NEURON ACTIVITY IN AN ACUTE INFLAMMATORY RAT BLADDER MODEL. Alvaro Lucioni, David Rapp, Edward Gong, Tamara Lotan, Daniel McGehee, Gregory Bales*.

21. ROBOTIC-ASSISTED LAPAROSCOPIC SACROCOLPOPEXY: THE UNIVERSITY OF CHICAGO EXPERIENCE. Alvaro Lucioni, David Rapp, Mark Lyon, William Stuart Reynolds, Edward Gong, Marcelo Orvieto, Gregory Bales*.

22. IMMUNOHISTOCHEMISTRY IN COMBINATION WITH IMMUNOFLUORESCENCE (IF) CONFOCAL MICROSCOPY AS AN EFFECTIVE TOOL OF HISTOPATHOLOGICAL ASSESSMENT OF ARCHIVAL HUMAN TISSUE. Adam Markaryan, Maria Tretiakova, Erik Nelson, Raul Hinojosa*.

23. MINIMIZING OPERATIVE TIME DURING RADICAL CYSTECTOMY. Albert A. Mikhail, Frederick Mendiola, Marcelo A. Orvieto, Lambda P. Msezane, Kevin C. Zorn, Benjamin R. Stockton, Gary D. Steinberg*.

24. ROBOTIC ASSISTED LAPRAOSCOPIC PROSTATECTOMY: FIRST 100 PATIENTS WITH MINIMUM 1-YEAR FOLLOW-UP. Albert A. Mikhail, Marcelo A. Orvieto, Benjamin R. Stockton, Ehab S. Billatos, Edward M. Gong, Alvaro Lucioni, Charles B. Brendler, Gregory P. Zagaja, Arieh L. Shalhav*.

25. LAPAROSCOPIC PARTIAL NEPHRECTOMY IN RENAL INSUFFICIENT PATIENTS. Albert A. Mikhail, Marcelo A. Orvieto, Edward M. Gong, Kevin C. Zorn, Frederick P. Mendiola, Alvaro Lucioni, Arieh L. Shalhav*.

26. SURAL NERVE GRAFTING IN ROBOTIC LAPAROSCOPIC RADICAL PROSTATECTOMY. Albert A. Mikhail, David H. Song, Marcelo A. Orvieto, Gary W. Chien, Benjamin R. Stockton, Arieh L. Shalhav*, Gregory P. Zagaja.

27. VOLTAGE-DEPENDENT CALCIUM CHANNELS OF DOG BASILAR ARTERY. Elena Nikitina, Babak S. Jahromi, Vitali A. Bouryi, Masataka Takahashi, Zhen-Du Zhang, R. Loch Macdonald*.

28. HIGH INTENSITY FOCUSED ULTRASOUND RENAL TISSUE ABLATION IN A LAPAROSCOPIC PORCINE MODEL. Marcelo A Orvieto, Mark B Lyon, Albert A Mikhail, Kevin C. Zorn, David E Rapp, Russell Fedewa, Ralf Seip, Narendra Sanghvi, Arieh L Shalhav*.

29. LAPAROSCOPIC ICE SLURRY COOLANT FOR RENAL HYPOTHERMIA. Marcelo A. Orvieto, Mark B Lyon, Albert A. Mikhail, Stephen R. Tolhurst, Albert A. Mikhail, John J. Oras, Kenneth E. Kasza, Arieh L. Shalhav*.

30. LAPAROSCOPIC CYST ABLATION FOR BOSNIAK IIF RENAL CYSTS: AN ALTERNATIVE TO EXTENDED FOLLOW UP. Marcelo A. Orvieto, Albert A Mikhail, Kevin C. Zorn, David E. Rapp, Glenn G. Gerber, Charles B. Brendler, Arieh L. Shalhav*.

31. RECOVERY OF RENAL FUNCTION AFTER COMPLETE RENAL HILAR VERSUS ARTERY ALONE CLAMPING DURING OPEN AND LAPAROSCOPIC SURGERY. Marcelo A. Orvieto, Albert A. Mikhail, Mark B. Lyon, Kevin C. Zorn, Frederick Mendiola, Edward M. Gong, Arieh L. Shalhav*.

32. LAPAROSCOPIC VS. OPEN SURGERY IN PATIENTS WITH ILEOCOLONIC CROHN’S DISEASE: A PROSPECTIVE COMPARATIVE STUDY. Stephanie L. Peng, Michele A. Rubin, Roger D. Hurst, Alessandro Fichera.

33. ASSESSMENT OF THE CORE LEARNING OBJECTIVES EDUCATIONAL MODEL IN THE UROLOGY CLERKSHIP FOR MEDICAL STUDENTS. Edward M Gong, David E Rapp, Alvaro Lucioni, Marcelo Orvieto, and Gregory P Zagaja*.

34. BOTULINUM TOXIN TYPE A INHIBITS BLADDER SENSORY NERVE ACTIVITY IN A CHRONIC INFLAMMATORY RAT BLADDER MODEL. Alvaro Lucioni, David Rapp, Katherine Turk, Tamara Lotan, Daniel McGehee, Sean Cook, Gregory Bales*.

35. TRANSVAGINAL REPAIR OF VAGINAL VAULT PROLAPSE: GYNECARE PROLIFT SYSTEM. Alvaro Lucioni, David Rapp, William Stuart Reynolds, Marc Chuang, Edward Gong, Marcelo Orvieto, Gregory Bales*.

36. A NOVEL SURGICAL SKILLS TRAINING ASSESSMENT TOOL TO FACILITATE QUALITY-BASED SURGICAL EDUCATION. Paul Roach, Hank Schmidt, Kevin Roggin, Josh Hemmerich, William Dale, Gene Selkov, Mitchell Posner*, Jonathan Silverstein*.

37. ACOUSTIC RHINOMETRY EVALUATION FOR RADIOFREQUENCY ABLATION OF THE TURBINATES. Girapong Ungkhara, Asli Sahin Yilmaz, Jacquelynne P. Corey*.

38. A NOVEL METHOD OF GENE DELIVERY AS THERAPY FOR HEPATIC COLORECTAL METASTASES USING CONTROLLED RELEASE NANOPARTICLES. Hank Schmidt, Jula Veerapong, Kai Bickenbach, Ralph Weichselbaum, Mitchell Posner*.

39. INTRAPERITONEAL ADMINISTRATION OF A MUTANT HERPES SIMPLEX VIRUS (HSV) ACHIEVES SYSTEMIC CYTOTOXICITY IN TUMORS THAT OVEREXPRESS MEK: A NOVEL ONCOLYTIC STRATEGY. Jula Veerapong, Kai Bickenbach, Kerrington Smith, Hank Schmidt, Bernard Roizman Ralph Weichselbaum, Mitchell Posner*.

40. THE VERSATILITY OF FREE STYLE THIGH PERFORATOR FLAPS FOR RECONSTRUCTION OF THE HEAD, NECK AND UPPER EXTREMITY. Mark T. Villa, Alvin B. Cohn, Lawrence J. Gottlieb*.

41. INFECTION OF LISTERIA MONOCYTOGENES PREVENTS TOLERANCE INDUCTION AND BREAKS ESTABLISHED TOLERANCE IN MOUSE HEART TRANSPLANTATION MODEL. Tongmin Wang, Lianli Ma, Ping Zhou, Dengping Yin, Jikun Shen, Luqiu Chen, Honglin Xu, Chyung-Ru Wang, Marisa Alegre, Anita Chong*.

42. RECEPTOR-OPERATED TRPC1 AND TRPC4 CHANNELS ACTIVATED BY ENDOTHELIN-1 IN VASCULAR SMOOTH MUSCLE CELLS AFTER SUBARACHNOID HEMORRHAGE. An Xie, Yasuo Aihara, Vitali A. Bouryi, Elena Nikitina, Zhen-Du Zhang, R. Loch Macdonald*.

43. REDUCTION IN CALCIUM SPARKS AS A CAUSE OF EXPERIMENTAL CEREBRAL VASOSPASM IN DOGS. Zhen-Du Zhang, Masataka Takahashi, Babak S Jahromi, Daven P Ryan, Serguei Y Cheranov, Jonathan H Jaggar, R. Loch Macdonald*.

44. OXYGENATED UNIVERSITY OF WISCONSIN SOLUTION FOR 24-HOUR PANCREAS PRESERVATION: EQUIVALENT TO TWO-LAYER METHOD? Xiangyang Zhao, Jikun Shen, Ryan Skarbek, Matthew Connors, James Michael Millis, Marc Rider Garfinkel*.

45. EVALUATION OF PATIENT RISK FACTORS AND TUMOR CHARACTERISTICS THAT CONTRIBUTE TO DIFFICULTY OF LAPAROSCOPIC RENAL SURGERY. Alvaro Lucioni, Edward Gong, Kevin Zorn, Marcelo Orvieto, Albert Mikhail, Glenn Gerber, Arieh Shalhav*.

46. ROBOTIC ASSISTED LAPAROSCOPIC PROSTATECTOMY: OUTCOMES OF THE FIRST 300 CASES. Kevin Zorn, Albert Mikhail, Marcelo Orvieto, Gary Chien, Gregory Zagaja, Arieh Shalhav*.

47. EFFECT OF PROSTATE WEIGHT ON OPERATIVE AND POSTOPERATIVE OUTCOMES OF ROBOTIC ASSISTED LAPAROSCOPIC PROSTATECTOMY. Kevin Zorn, Marcelo Orvieto, Albert Mikhail, Shang Lin, Anthony Schaeffer, Mark Lyon, Arieh Shalhav*, Gregory Zagaja.

48. MINIMIZING KNOT TYING DURING RECONSTRUCTIVE LAPAROSCOPIC UROLOGY. Kevin Zorn, Marcelo Orvieto, Albert Mikhail, Gary Chien, Gregory Zagaja, Arieh Shalhav*.

SESSION II

Moderator:

Jai Raman, M.D., Ph.D.
Associate Professor
Department of Surgery
Section of Cardiac and Thoracic Surgery

MICROENCAPSULATION OF PANCREATIC ISLETS WITHIN GLP-1 FUNCTIONALIZED POLY (ETHYLENE GLYCOL) (PEG) HYDROGEL USING SELECTIVE WITHDRAWAL. Seda Kizilel, Jason L Wyman, Patrick Zhao, Matthew Connors, Sidney Nagel, Milan Mrksich, and Marc R Garfinkel*.

IDENTIFYING PEPTIDE TARGETS AND T CELLS FOR CEA-DIRECTED IMMUNOTHERAPY USING A TRANSGENIC MURINE MODEL .Haixi Miao, Matthew E. Brown, Mark D. McKee.

RECOGNITION OF INTESTINAL EPITHELIAL HIF-1a ACTIVATION BY PSEUDOMONAS AERUGINOSA. Nachiket Patel, Olga Zaborina, Yingmin Wang, Licheng Wu, Olga Schevchenko, Jonathan Kohler, Sean Colgan, Jerrold Turner, John Alverdy*.

OSTEOSARCOMA AND OSTEOBLASTIC DIFFERENTIATION: A NEW PERSPECTIVE ON ONCOGENESIS AND TREATMENT. Rex Haydon, Hue Luu, Chris Song, Xioji Luo and Tong-Chuan He.

LONG-TERM CANCER CONTROL IN A LARGE SINGLE SURGEON SERIES OF OPEN RADICAL RETROPUBIC PROSTATECTOMY. Marcelo A. Orvieto, Nejd F. Alsikafi, Brett A. Laven, Arieh L. Shalhav, Gregory P. Zagaja, Gary D. Steinberg, Charles B. Brendler*.

OPIOIDS FUNCTION AS HOST-DERIVED BACTERIAL SIGNALING COMPOUNDS DURING MAMMALIAN STRESS. Olga Zaborina, Vesta Valuckaite, Mae Ciancio, Yimei Chen, Terry Li, Jerrold R Turner, Eugene Chang, John C Alverdy.

THE GENETIC BASIS OF DELAYED TUMOR NECROSIS FACTOR - ALPHA (TNFá) – MEDIATED TUMOR CELL DEATH. Mukta Katdare, Elena Efimova, Michael Garafol, Thomas Darga , Sato Nakamura, Ralph Weichselbaum, Mitchell Posner*.

FACTORS CORRELATED WITH SUCCESSFUL HUMAN ISLET TRANSPLANTATION: REVIEW OF 29 HUMAN ISLET ISOLATIONS FROM THE UNIVERISTY OF CHICAGO’S HUMAN ISLET TRANSPLANTATION TEAM. Xiangyang (Patrick) Zhao, Matthew Connors, Monalee Shah, Seda Kizilel, Yang Wang, Ryan Skarbek, Marc Rider Garfinkel*