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Clinical Protocols

To view the research protocols for a particular specialty, select the specialty from the menu below. Where the studies below are listed in ClinicalTrials.gov and are actively recruiting patients, a link is provided to the corresponding site.


Visit the Cardiothoracic research page for more information.

InvestigatorTitleRelated Links
Mark Ferguson

A double-blind, randomized, placebo-controlled Phase III study to assess the efficacy of recMAGE-A3 + AS15 Antigen-Specific Cancer Immunotherapeutic as adjuvant therapy in patients with resectable MAGE-A3-positive Non-Small Cell Lung Cancer

Accuracy of Physician Estimates in Assessing the Risk of Major Lung Resection

ACOSOG Z0040: A Prospective Study of the Prognostic Significance of Occult Metastases in the Patient With Resectable Non-small Cell Lung Carcinoma

ACOSOG Z4051: A Phase II Study of Neoadjuvant Therapy with Cisplatin, Docetaxel, Panitumumab Plus Radiation Therapy Followed By Surgery in Patients with Locally Advanced Adenocarcinoma of the Distal Esophagus

Assessing the Need for Future Improvements in Lung Cancer Surgery Via Review of Historical Outcomes

Correlative Research in General Thoracic Surgery

Improving the Prediction of Postoperative Pulmonary Function After Major Lung Resection - A Pilot Study

Minimally Invasive Esophagectomy (MIE): A Multicenter Feasibility Study

Optimal Management of Barrett's Esophagus with High Grade Dysplasia: Decision Analysis

Research Screening Protocol and Patient Database for Thoracic Surgery

Dr. Ferguson's clinical research
Valluvan Jeevanandam A Prospective, Randomized, Controlled, Un-blinded, Multi-Center Clinical Trial to Evaluate the HeartWare Ventricular Assist System for Destination Therapy of Advanced Heart Failure

Evaluation of the HeartWare LVAD System for the Treatment of Advanced Heart Failure

Evaluation of the HeartWare® Ventricular Assist System for the Treatment of Advanced Heart Failure - Continued Access Protocol

Interagency Registry of Mechanically Assisted Circulatory Support

Left Ventricular Assist Device Related Infections in Bridge-to-Transplant Versus Destination Therapy Patients Using Continuous Flow Devices
Wickii Vigneswaran

CALGB 140503: A Phase III Randomized Trial of Lobectomy versus Sublobar Resection for Small (d 2 cm) Peripheral Non-Small Cell Lung Cancer

Quality of Life Following Surgery in the Management of Malignant Pleural Mesothelioma Patients


General Surgery

Visit the General Surgery research page for more information.

InvestigatorTitleRelated Links
John Alverdy Effect of Intestinal Pseudomonas Aeruginosa on the Critically Ill Patient Dr. Alverdy's lab
Peter Angelos Long-Term Outcomes of Endocrine Surgery Patients

New Pediatric Surgeons and the Informed Consent Process
Nora Jaskowiak

A Pilot Study of Chemo-prevention of Green Tea in Women with Ductal Carcinoma in Situ (DCIS)

NSABP-P-2: Study Comparing Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer

Edwin Kaplan Investigation of Primary Hyperparathyroidism in Young Populations at the University of Chicago Hospitals  
Vivek Prachand Surgical Management of Obesity: A Retrospective Cohort Study of Patients Treated with Bariatric Surgery

Bariatric Outcomes Longitudinal Database (BOLD)
Kevin Roggin Evaluation of KOC in Pancreatic Cyst Fluid

Laparoscopic Resections for Gastric GIST

Molecular Determinants of Malignancy in Pancreatic Cystic Neoplasms

Percutaneous Cholecystostomy

Pilot study to assess the safety and efficacy of percutaneous diagnostic peritoneal lavage to sample peritoneal cytology in patients with advanced gastric cancer

Preoperative Predictors of Mortality, Morbidity and Quality of Life in Patients Undergoing Pancreaticoduodenectomy


Visit the Neurosurgery research page for more information.

InvestigatorTitleRelated Links
Issam Awad Inflammatory and Signaling Pathways in Resected Cerebrovascular Malformations (CVMs)  
David Frim

Feasibility Study of the Medtronic InSite ICP Monitoring System (Medtronic Protocol 0101-Revision B)

Hydrocephalus, Intracranial Pressure, and Neurocognition

International Infant Hydrocephalus Study

Neurosurgical Outcomes Study

Outcomes in Patients Undergoing Surgical Intervention for Chiari Type 1 Malformation with Syringomelia

Pivotal IDE Study of the Bryan Cervical Disc Prosthesis in the Treatment of Degenerative Disc Disease

Retrospective Chart Review of Patients with Chiari Malformation, Pseudotumor, and other CSF-Related Abnormalities

Retrospective Review of the Surgical Treatment of Congenital Malformation of the Nervous System

Ventriculostomy Research Study

Javad Hekmatpanah A Retrospective Chart Review of Patients Undergoing Surgery for CNS Tumors: Trends and Outcomes

Head Injury in Abused and Neglected Children

Magnetic Resonance Anatomic Brain Imaging as a Guide to Neurosurgical Landmarks
Maciej Lesniak

A Phase IIa Study of ADV-TK + Valacyclovir Gene Therapy in Combination with Standard Radiation Therapy for Malignant Gliomas

Compassionate Use of PF-4948568 with Radiation and Temozolomide in Patients with Newly Diagnosed Glioblastoma Multiforme

Neuro-Oncology Clinical Research Protocol

Retrospective Immunohistological Study of the Expression of Brim1 and Kiss1 in human metastatic and primary tumors

The Use of Human Brain Tumor Tissue for Adenoviral Gene Therapy

Dr. Lesniak's lab
Ben Roitberg Spine Outcomes Study  

Ophthalmology & Visual Sciences

Visit the Ophthalmology research page for more information.

InvestigatorTitleRelated Links
Seenu Hariprasad A Multicenter Randomized Study Evaluating Dosing Regimens for Treatment With Intravitreal Ranibizumab Injections in Subjects With Macular Edema Following Retinal Vein Occlusion

A Phase III, Double-Masked, Multicenter, Active Treatment-Controlled Study of the Efficacy and Safety of 0.5 mg and 2.0 mg Ranibizumab Administered Monthly or on an As-Needed Basis (PRN) in Patients with Subfoveal Neoascular Age-Related Macular Degeneration

Intravitreal dexamethasone implant (Ozurdex) in the treatment of refractory macular edema secondary to retinal vein occlusions

Use of the visual function questionnaire to assess the impact of diabetic macular edema on vision-related quality of life and patient perception of treatment outcomes
Rima McLeod Consent to receive spiramycin to attempt to prevent congenital toxoplasmosis. (Compassionate use of spiramycin)

Pathogenesis, outcome, treatment and prevention of toxoplasmosis. Longitudinal follow-up to determine outcome of toxoplasmosis

Pathogenesis, Outcome, Treatment, & Prevention of Congenital Toxoplasmosis. Adults who Provide a Blood Sample by Venipuncture, or Provide a Saliva Sample Obtained by a Self-Collection Kit. (Studies of Immune Responses to T. Gondii and Genetics of Resistance to this Infection)

Pathogenesis, Outcome, Treatment, & Prevention of Toxoplasmosis, Treatment with Pyrimethamine and Sulfadiazine for One Year For Treatment of Congenital Toxoplasmosis

Pathogenesis, Outcome, Treatment, and Prevention of Toxoplasmosis. Longitudinal Follow-up to Determine Outcome of Untreated Congenital Toxoplasmosis (Historical Patients)

Pathogenesis, Outcome, Treatment, and Prevention of Toxoplasmosis. Why Individuals Infected in Utero Become Ill Due to Their Congenital Toxoplasmosis

Pregnancy on Immunity to Toxoplasma Gondii

Toxoplasmosis -Evaluation of Tissues

Use of Intraocular Injection of Antibody to VegF for Treatment of Active Choroidal Neovascular Membranes in Ocular Toxoplasmosis

Otolaryngology/Head & Neck Surgery

Visit the Otolaryngology research page for more information.

InvestigatorTitleRelated Links
Fuad Baroody Bacterial Microbiota In The Tonsils Of Children Undergoing Adenotonsillectomy And Normal Controls

Image Analysis as a Tool in Diagnosis of Chronic Sinusitis and Tumors of the Paranasal Sinuses

Mechanism of action of fluticasone furoate in childhood obstructive sleep apnea syndrome (OSAS)

Obstructive sleep apnea in children under 3 years of age: Persistence of disease after adenotonsillectomy
Elizabeth Blair Analysis of Salivary Gland Tumors Treated at the University of Chicago

Identifying Disparities in Head and Neck Squamous Cell Cancer Clinical Trial Participation at the University of Chicago Medical Center
Jacquelynne Corey A comparison study between cefdinir and amoxicillin/clavulanate in patients with acute sinusitis for assessment of quality of life (QOL)

Observational Study of Inhalant Allergen Specific Immunotherapy

Survey of Allergy Immunotherapy Post Treatment (SAIPT)

The Effect of Intranasal Steroids on the Nasal Cycle

Utility of Acoustic Rhinometry to Predict the Outcome of Radiofrequency Ablation of the Turbinates
Robert Naclerio A Parallel Group Observational Study of the Effects of Allergic Rhinitis on the Nasal/Sinus Microbiome

A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial of Topical Allstate in the Prevention of the Signs and Symptoms of the Acute Response to Nasal Allergen Challenge (CETALY0001)

Comparison of Intraoperative Bleeding during Endoscopic Sinus Surgery between Patients Receiving Total Intravenous Anesthesia with Propofol and Patients Receiving an Inhalational Anesthetic with Sevoflurane

Effect of Prednisone on Peripheral Blood T-cell function (Tregs and Th17) in Patients with Chronic Rhinosinusitis (CRS)

Effect of Veramyst and Olopadatine 0.2% Opthalmic Solution Alone and in Combination on the Nasal and Ocular Symptoms of the Early Reaction to Nasal Challenge with Allergen

Evaluation of NasoNeb" Delivery of an Intranasal Steroid in the Treatment of Perennial Allergic Rhinitis

Nasal Challenge with Antigen

The Addition of Vitamin D to Fluticasone Propionate in the Management of Seasonal Allergic Rhinitis
 Dr. Naclerio's research
Jayant Pinto

A Randomized, Clinical Trial of a Novel Immunotherapy for Chronic Sinusitis:Vitamin D

Genetic Factors in Chronic Sinusitis

Genetic Factors in Olfactory Dysfunction

Is the Cytokine Profile of Patients with Chronic Sinusitis Skewed Toward a TH2 Response?

The Sinonasal Microbiome

Dr. Pinto's research
Dana Suskind Efficacy of LENA System Feedback Reports of Affecting Caregiver Behavior

Efficacy of Pilot Project ASPIRE in Affecting Parental Knowledge and Skills

Parent Focus Groups for the Development of a Parent-Directed Educational Program on Early Childhood Language Development

Thirty Million Words Project: A Feasibility Trial

Pediatric Surgery

Visit the Pediatric Surgery research page for more information.

Plastic and Reconstructive Surgery

Visit the Plastic Surgery research page for more information.

InvestigatorTitleRelated Links
Lawrence Gottlieb Behaviors of Children Ages 15 months to Five Years Around Microwave Ovens

Comparison of Two Methods of Negative Pressure Wound Therapy: VAC and G-SUC for Treatment of Surgical or Traumatic Wounds

Comparison of Two Methods of Securing Skin Grafts Using Negative Pressure Wound Therapy: VAC and G-SUC

Composite Tissue Allotransplantation in Patients with Solid Organ Allograft

Novel use of a V-Y regional advancement flap for closure of anterolateral thigh free flap donor sites

Surgical Management of Mediastinitis in the Pediatric Patient
Russell Reid Distraction Osteogeneis versus Tracheostomy: An analysis of cost and airway improvement

Molecular and Immunologic Basis for Craniofacial Suture Biology and Craniosynostosis

Reconstruction of complex meningomyelocele wounds: an outcomes study
David Song A Phase 2, Multicenter, Double-Blind, Placebo-Controlled Study of GBT009 for Treatment of Incisional Wounds Following Breast Reconstruction Surgery

Aesthetic Breast Conservation Surgery: the development and application of the tumor-breast index

Optimizing Outcomes in Breast Conservation Therapy
Lawrence Zachary Body Contouring in the Post-Bariatric Surgery Patient  


Visit the Transplantation research page for more information.

InvestigatorTitleRelated Links
Yolanda Becker Kidney Transplantation in Patients on Clopidogrel: Is there an Increase in Peri-Operative Complications?  
J. Michael Millis A 24 month multi-center, open-label, randomized, controlled study to evaluate the efficacy and safety of concentration-controlled everolimus to eliminate or to reduce tacrolimus compared to tacrolimus in de novo liver transplant recipients (CRAD001H2304)

A randomized, open label, parallel-group, multi-center trial to compare the efficacy and safety of TachoSil®
versus Surgicel® Original for the secondary treatment of local bleeding in adult and pediatric patients undergoing hepatic resection surgery (TC-2402-040-SP)

Long Term Year Follow Up of Live Liver Donors

Multi-Center Study Evaluating Novel Variants in the Human Genome as Determinants of Tissue Compatibility in Renal Transplant and Combined Bone Marrow/Renal Transplant Recipients

Solid Organ Transplantation in HIV: Multi-Site Study

SPLIT Studies of Pediatric Liver Transplantation
J. Richard Thistlethwaite A 12 month, multi-center, randomized, open-label non-inferiority study comparing the safety and efficacy of concentration-controlled Everolimus with low dose tacrolimus to CellCept® (mycophenolate mofetil) with standard dose tacrolimus in de novo renal transplant recipients

A Facilitated Access Program to Provide Everolimus (RAD) for Maintenance Patients Completing Therapy in RAD Trials in Solid Organ Transplantation (CRAD001 A2401)

Belatacept Conversion Trial in Renal Transplantation

Belatacept Evaluation of Nephroprotection and Efficacy as First-Line Immunosuppression Trial (BENEFIT) (IM103008)

Belatacept Evaluation of Nephroprotection and Efficacy as First-Line Immunosuppression Trial- EXTended Criteria Donors (BENEFIT-EXT) (IM103027)
Dr. Thistlethwaite's lab
Piotr Witkowski Pyrimidine Levels in Patients with Kidney Disease Dr. Witkowski's lab


Visit the Urology research page for more information.

InvestigatorTitleRelated Links
Gregory Bales Sexual Satisfaction of Women with Pelvic Organ Prolapse and Their Male Partners  
Scott Eggener A Prospective, Multi-Center PRostate Cancer Individual Signature Evaluation Trial (PReCISE) in Patients Undergoing Scheduled Prostate Biopsy

CALGB 140602/ NCIC PR.11: A Phase III Study of Active Surveillance Therapy Against Radical Treatment In Patients Diagnosed With Favourable Risk Prostate Cancer (START)

CALGB 70807: The Men's Eating and Living (MEAL) Study: A Randomized Trial of Diet to Alter Disease Progression in Prostate Cancer Patients on Active Surveillance

Pathologic Upstaging in Prostate Cancer Patients on Watchful Waiting

Randomized, Multi-Institutional Trial of Ciprofloxacin versus Observation for Men with an Elevated Prostate Specific Antigen (PSA)

Significance of Solitary Rib Abnormalities on Bone Scan for Clinically Localized or Biochemically Recurrent Prostate Cancer
Mohan Gundeti A Database of Patients Undergoing Surgery (Treatment) for Congenital Urological Anomalies

Comparison of Ergonomics in Open, Laparoscopic, and Robotic Pyeloplasty Using a Porcine Model

Pediatric Patients undergoing Robotic-Assisted Laparoscopic Surgery

Pilot study of neurophysiologic recording and nerve identification during extra-vesical ureter-reimplantation
Arieh Shalhav Clinical Care Pathway to Decrease Hospital Stay After Laparoscopic or Robotic Partial Nephrectomy: Factors Predictive for Success

Clinical Urology Research Screening Protocol

Minimally Invasive Renal Surgery: Multiinstitutional Experience of Patients Undergoing Laparoscopic and Robotic-Assisted Nephron Sparing Renal Surgery

Gary Steinberg A Multicenter, Randomized Placebo-Controlled, Double Blind, Phase 3 Trial of Single-Dose Intravesical EOquin as a Surgical Adjuvant Instilled in the Early Postoperative Period in Patients Undergoing Transurethral Resection for Noninvasive Bladder Cancer

A Phase 1 Open Label Exploratory Study of an Autologous Neo-Urinary Conduit in Subjects Requiring Incontinent Urinary Diversion Following Radical Cystectomy

A Phase 3, Randomized, Active-Controlled, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of EN3348 (MCC) as Compared with Mitomycin C in the Intravesical Treatment of Subjects with BCG Recurrent or Refractory Non-Muscle Invasive Bladder Cancer

A Phase 4, Multicenter, Double-Blind, Placebo-Controlled, Parallel Study of Alvimopan for the Management of Postoperative Ileus in Subjects Undergoing Radical Cystectomy

A Randomized Controlled Trial Assessing the Effects of a Post-operative Hospitalist Consult in Patients Undergoing Radical Cystectomy

Bladder Cancer Sample Collection

CALGB 9687: The Role of Salvage Prostatectomy for Radiation Failure In Prostate Carcinoma: A Phase II Trial

Clinical Utility of The Vysis UroVysion Test and the Optimal Surveillance Strategies for Patients with Transitional Cell Carcinoma of the Bladder

Detection of Bladder Cancer by Microsatellite Analysis (MSA) of Urinary Sediment: Multi-Institutional Study

Evaluation of the UroVysion Test in Predicting Recurrence and/or Progression of Disease in Patients Receiving Initial BCG or BCG plus Interferon Therapy for Primary High Grade Papillary and CIS Urothelial Carcinoma of the Bladder

Multi-Institutional Evaluation and Quality of Care Initiative for the Management of Muscle Invasive Bladder Cancer

MVAC in Organ-Confined Bladder Cancer Based on p53 Status

Normal Subject Urine Sample Collection

Open-Label, Multi-Center Study of the Efficacy and Safety of MCC in the Treatment of Patients with Non-Muscle Invasive (Superficial) Bladder Cancer at High Risk of Progression and Who are Refractory to BCG

Prospective Multi-Center Evaluation of High Grade T1 Bladder Cancer Protocol

Quality of Life After Cystectomy
Donald VanderGriend Access to existing patient database to request archived tissue

Acquisition of fresh and frozen tissue from urological surgical specimens
Gregory Zagaja Phase II, Randomized, Double-blind, Multi-centered Study of Polyphenon E in Men with High-Grade Prostatic Intraepithelial Neoplasia (HGPIN) and Atypical Small Acinar Proliferation (ASAP)

Quality of Life After Radical Prostatectomy

Randomized controlled trial of early removal of urethral catheter with suprapubic tube drainage versus urethral catheter drainage alone following robot-assisted laparoscopic radical prostatectomy

Randomized Placebo-Controlled Adjuvant Study of Prevention of Prostate Cancer Recurrence After Radical Prostatectomy by Soy Protein Isolate

Vitamin D levels and related genetic polymorphisms, sun exposure, skin color and risk of aggressive prostate cancer

Vascular Surgery and Endovascular Therapy

Visit the Vascular Surgery research page for more information.

InvestigatorTitleRelated Links
Christopher Skelly Coronary angioplasty in Vascular patients

Radiographic Characteristics of Carotid Plaque and Predictors of Symptomatic Disease

Stenting and Angioplasty With Protection in Patients at High-Risk for Endarterectomy

Structural and Molecular Determinants of Carotid Atherosclerotic Plaque Tissues

Use of Saphenous Veins from Leg Amputations for ex vivo Intimal Hyperplasia Model

Venous ex vivo Intimal Hyperplasia Model