Clinical Protocols
To view the research protocols for a particular specialty, select the specialty from the menu below. Where the studies below are listed in ClinicalTrials.gov and are actively recruiting patients, a link is provided to the corresponding site.
Cardiothoracic
Visit the Cardiothoracic research page for more information.
| Investigator | Title | Related Links |
|---|---|---|
| Mark Ferguson | Minimally Invasive Esophagectomy (MIE): A Multicenter Feasibility Study ACOSOG Z0030: Randomized Trial of Mediastinal Lymph Node Sampling versus Complete Lymphadenectomy during Pulmonary Resection in the Patient with N0 or N1 (less than hilar) Non-Small Cell Carcinoma ACOSOG Z0040: A Prospective Study of the Prognostic Significance of Occult Metastases in the Patient With Resectable Non-small Cell Lung Carcinoma |
More on Dr. Ferguson's clinical research |
| Mahesh Gupta | Expression of Contractile Proteins in the Failing Heart | Dr. Gupta's lab |
| Valluvan Jeevanandam | Clinical Trial of the On-X Valve Using Low Dose Anticoagulation Prospective, Multi-Center, Safety and Effectiveness of the Organ Care System Device for Cardiac Use Clinical Evaluation of the Jarvik 2000® Heart Assist System |
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| Bassem Mora | Congenital Heart Surgeons' Society Pulmonary Conduit Study Congenital Heart Surgeons' Society Tricuspid Atresia Study Contegra Valve as Alternative to Homograft |
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| Jai Raman | Bone Healing Following Median Sternotomy: A retrospective Comparison of Rigid Internal Fixation Versus Wire Circlage Post-Operative Follow-up of Patients Undergoing Radio-Frequency Ablation or Cyro-Ablation Based Maze Procedures for Atrial Fibrillation Can Cardiac Support (Vest) Reduce Sternal Pain and Improve Patients Outcome After Cardiac Surgery? |
More on Dr. Raman's clinical research |
General Surgery
Visit the General Surgery research page for more information.
| Investigator | Title | Related Links |
|---|---|---|
| John Alverdy | Virulence Phenotype of Gram Negative Hospital Bacterial Strains | Dr. Alverdy's lab |
| Peter Angelos | Long-Term Outcomes of Endocrine Surgery Patients | Dr. Angelos is Associate Director for the MacLean Center for Clinical Medical Ethics |
| Alessandro Fichera | Timing of Rectal Cancer Response to Chemoradiation A Phase II Trial of Neoadjuvant Chemoradiation and Local Excision for uT2uNo Rectal Cancer The Study of Gastrointestinal Cancers in Patients with Inflammatory Bowel Disease (IBD) |
More on Dr. Fichera's clinical research |
| Nora Jaskowiak | Study Comparing Tamoxifen and Raloxifene for the Prevention of Breast Cancer | |
| Edwin Kaplan | Investigation of Primary Hyperparathyroidism in Young Patient Populations at the University of Chicago Hospitals | |
| Mark McKee | Melanoma Tissue Collection for Immunologic Studies | Dr. McKee's lab (note this site is still under construction but should be up shortly) |
| Michael Morowitz | Ribosomal Gene Sequence Analysis of Intestinal Microbiota in Necrotizing Enterocolitis | |
| Mitchell Posner | A Randomized, Phase II/III, Study of TNFerade Biologic with 5-FU and Radiation Therapy for First-Line Treatment of Unresectable Locally Advanced Pancreatic Cancer | |
| Vivek Prachand | Surgical Management of Obesity: A Retrospective Cohort Study of Patients Treated with Bariatric Surgery Bariatric Outcomes Longitudinal Database (BOLD) |
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| Kevin Roggin | Identification of Markers of Susceptibility for Oncolytic Therapy with Herpes Simplex 1 (HSV-1) in Pancreatic Cancer Preclinical Study to Identify Molecular Signature for Malignant Pancreatic Mucinous Cystic Neoplasm Preoperative Predictors of Mortality, Morbidity and Quality of Life in Older Patients Undergoing Pancreaticoduodenectomy for Pancreatic Head Adenocarcinoma: A Pilot Study |
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| Jonathan Silverstein | Quality-Based Surgical Education & The Surgical Training and Assessment Tool (QBST-STAT) | More on Dr. Silverstein's work |
Neurosurgery
Visit the Neurosurgery research page for more information.
| Investigator | Title | Related Links |
|---|---|---|
| Frederick Brown | Pivotal IDE Study of the Bryan Cervical Disc Prosthesis in the Treatment of Degenerative Disc Disease Is Bilateral Instrumentation Necessary in Minimally Invasive Transforaminal Lumbar Interbody Fusion? A Prospective, Multi-Center, Randomized Controlled Study to Compare the Spinal Sealant System as an Adjunct to Sutured Dural Repair with Standard of Care Methods During Spinal Surgery |
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| David Frim | Hydrocephalus, Intracranial Pressure, and Neurocognition Feasibility Study of the Medtronic InSite ICP Monitoring System (Medtronic Protocol 0101-Revision B) International Infant Hydrocephalus Study |
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| Javad Hekmatpanah | Head Injury in Abused and Neglected Children Magnetic Resonance Anatomic Brain Imaging as a Guide to Neurosurgical Landmarks |
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| Maciej Lesniak | A Phase I/II Dose Escalation Study of Locally Administered OncoGel in Subjects with Recurrent Glioma A Phase II/III Randomized Study of CDX-110 with Radiation and Temozolomide in Patients with Newly Diagnosed Glioblastoma Multiforme A Phase 2, Multicenter, Exploratory Study, Evaluating the Treatment Effect of Surgery Plus Gliadel Wafer in Patients with Metastatic Brain Cancer |
Dr. Lesniak's lab |
| Catherine Ojakangas | Cortical and Basal Ganglia Function During Motor Learning in Movement Disorders Cerebral Mechanisms of Human Skills Learning |
Dr. Ojakangas' lab |
| Richard Penn | Brain Water Content Measurement Using MRI Outcomes Study: Deep Brain Stimulation for the Treatment of Dystonia The Use of MRI for the Assessment of Brain Drug Infusion in Patients with Huntington's Chorea |
Dr. Penn's lab |
Orthopaedic and Rehabilitation Medicine
Visit the Orthopaedic research page for more information.
| Investigator | Title | Related Links |
|---|---|---|
| Henry Finn | Balance® Microplasty Hip System Data Collection | |
| Tong-Chuan He | Analysis of the Beta-Catenin Signaling Pathway in Human Cancers | Dr. He's lab |
| Sherwin Ho | OBI Investigation of Chondral Injuries | |
| Purnendu Gupta | Leadership Styles: A Comparative Study of Physician and Senior Administrative Leaders | |
| David Manning | Anticoagulation Prophylaxis for Elective Total Joint Arthroplasy in Patients with Previous History of Pulmonary Embolus | |
| John Martell | A Prospective Randomized Wear Study of a Crosslinked Polyethylene Bearing System in Total Hip Arthroplasty Computer Assisted Determination of Leg Length Discrepancy A Computerized Predictive Model for Risk Subsequent Slipped Capital Femoral Epiphysis |
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| Daniel Martin | Benign Mass Lesions of the Vocal Folds: A Comparison of Clinical and Histopathologic Diagnoses | |
| Daniel Mass | Ascension Proximal Interphalangeal (PIP), FDA Humanitarian Device Exemption (HDE) #H010005 Evaluation of the DePuy Anchor Peg Glenoid for Radiographic Evidence of Loosening and Bio-Ingrowth in Total Shoulder Arthroplasty |
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| Terrance Peabody | Evaluation of Prognostic Factors in Adult with Soft-Tissue Sarcomas | |
| Bruce Reider | The Prevalence of Meniscal Tears and the Clinical Course in Patients Age 35-55 with Medial Joint Line Tenderness and Normal Radiographs The Role of the Anterior Cruciate Ligament in Proprioception in the Knee |
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| Michael Terry | Management of Early Hip Osteoarthritis with Mechanical Symptoms: The Efficacy of Treatment with Arthroscopic Intervention (A Single-Blind, Randomized, Controlled, Single-Center Study of the Efficacy of Arthroscopic Intervention with Corticosteroid Injection Versus Corticosteroid Injection Alone in the Management of Early Hip Osteoarthritis as Assessed by the Harris Hip Score Evaluation) | |
| Brian Toolan | Prospective, Randomized, Controlled Trial of Two Reconstructive Procedures to Treat Adult Acquired Flatfoot. Retrospective Review of Distal Tibio-Fibular Fusions for Treating Missed Syndesmotic Injuries |
Otolaryngology/Head & Neck Surgery
Visit the Otolaryngology research page for more information.
| Investigator | Title | Related Links |
|---|---|---|
| Fuad Baroody | Local and systemic cytokine profiles in children with obstructive sleep apnea and controls Mechanism of Action of Fluticasone Furoate in Childhood Obstructive Sleep Apnea Syndrome (OSAS). Safety and Efficacy Evaluation of Topical Moxidex Otic Solution Compared to Moxifloxacin Solution in the Treatment of Acute Otitis Media with Otorrhea through Tympanostomy Tubes |
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| Jacquelynne Corey | A Comparison Study Between Cefdinir and Amoxicilline/Clavulonate in Patients with Acute Sinusitis and Assessment of Quality of Life (QOL) Utility of Acoustic Rhinometry to Predict the Outcome of Radiofrequency Ablation of the Turbinates The Effect of Intranasal Steroids on the Nasal Cycle |
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| Raul Hinojosa | Histopathologic Studies of the Human Temporal Bones | |
| Ernest Mhoon | Middle Ear Transducer | |
| Robert Naclerio | Does the Response to a Nasal Decongestant Test Predict the Outcome to Treatment of Seasonal Allergic Rhinitis with Nasonex A Combination of Intranasal Steroid/Oxymetazoline Leads to Faster Relief of Nasal Congestion without Inducing Medicamentosa The Addition of Montelukast to Fluticasone in the Treatment of Perennial Allergic Rhinitis Effects of Anti-IgE Antibody Omalizumab (Xolair) on Patients with Chronic Sinusitis and a Positive Allergen Test Intranasal CO2 for Allergic Rhinitis |
More on Dr. Naclerio's clinical research |
| Jayant Pinto | Treatment of Olfactory Dysfunction in Seasonal Allergic Rhinitis Genetic Factors in Chronic Sinusitis Genetic Factors in Olfactory Dysfunction |
Dr. Pinto's lab |
| Kerstin Stenson | Tissue Procurement for Head and Neck Cancer Patients Undergoing Surgery or Biopsy | |
| Dana Suskind | Perceived Barriers to Pediatric Cochlear Implant Success Needs of Parents with Hearing Impaired Children for the Development of a Parented Directed Educational Program Obstructive Sleep Apnea in Children Under Three Years of Age: Persistence of Disease after Adenotonsillectomy |
Dr. Suskind's Research |
| Joseph Toljanic | Clinical Evaluation of a New One-Piece Dental Implant An Open, Prospective, Multicenter Study to Evaluate the Outcomes of Astra Tech implants, Fixture Microthread OsseoSpeed, in Patients with Totally Edentulous Maxillas and Poor Quality and Quantity in an Immediate Loading Protocol. A Clinical Evaluation of a One-Piece Ceramic Implant in Daily Use |
Pediatric Surgery
Visit the Pediatric Surgery research page for more information.
| Investigator | Title | Related Links |
|---|---|---|
| Mindy Statter | Blunt Intestinal Injuries in Children Laparoscopic Approaches to the Treatment of Hepatobiliary Disease in Children Transanal Endorectal Pull-Through for Hirschsprung's Disease: Early Outcome Study |
Plastic and Reconstructive Surgery
Visit the Plastic Surgery research page for more information.
| Investigator | Title | Related Links |
|---|---|---|
| Lawrence Gottlieb | Comparison of Two Methods of Negative Pressure Would Therapy: VAC and G-SUC for Treatment of Surgical or Traumatic Wounds Retrospective Analysis of Pleur-Evac Use Following Negative Pressure Assisted Wound Therapy on Pressure Sensitive Locations Retrospective Review of Biobrane Use and Long Term Outcomes in the Treatment of Partial Thickness Burn Injuries |
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| Raphael Lee | Multidisciplinary Evaluation and Treatment of Electrical Injury Poloxamer 188 Phase IA Clinical Trials |
Dr. Lee's lab |
| Russell Reid | Molecular and Immunologic Basis for Craniofacial Suture Biology and Craniosynostosis | |
| David Song | A Multicenter, Prospective, Open-Label Study to Assess the Clinical Outcomes of LTM Use in Two-Stage Breast Reconstruction Immediately Post-Mastectomy A Multicenter, Prospective Randomized Controlled Study to Evaluate the Clinical Outcomes of AlloDerm 1.0 vs. AlloDerm 2.0 in Two-Stage Breast Reconstruction Immediately Post-Mastectomy Oncoplastic Immediate Reconstruction of Breast Lumpectomy Defects |
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| Lawrence Zachary | Adjunct Study Protocol for Mentor Silicone Gel-Filled Mammary Prosthesis |
Transplantation
Visit the Transplantation research page for more information.
| Investigator | Title | Related Links |
|---|---|---|
| Marc Garfinkel | Allogenic Islet Cells (Human University of Chicago) Administered Via Intraportal Infusion; and Immunosuppressive Therapy Autologous Islet Cell Transplantation: The University of Chicago Experience Entera Therapy Gastric Electrical Stimulation System |
Dr. Garfinkel's lab |
| Robert Harland | Solid Organ Transplantation in HIV: Multi-Site Study (HIVTR) A Phase III, Randomized, Open-Label, Comparative, Multicenter Study to Assess the Safety and Efficacy of Prograf (tacrolimus)/MMF, Modified Release (MR) Tacrolimus/MMF and Neoral (cyclosporine)/MMF in de novo Kidney Transplant Recipients A Phase 2B, Randomized, Multicenter, Open-Label, Concentration-Controlled, Safety Study of ISA247 and Tacrolimus (Prograf) in De Novo Renal Transplant Patients (ISA05-01) |
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| J. Richard Thistlethwaite | Belatacept Conversion Trial in Renal Transplantation A 24-Month, Multicenter, Randomized, Open-Label Non-Inferiority Study of Efficacy and Safety Comparing Concentration-Controlled Certican in Two Doses (1.5 and 3.0 mg/day starting doses) with Reduced Neoral versus 1.44g Myfortic with Standard Dose Neoral in De Novo Renal Transplant Recipients (CRAD001A2309) A 4-Week, Multicenter, Double-Blind, Randomized, Parallel Group Study to Compare the Gastrointestinal Safety and Tolerability of Myfortic and MMF (Cellcept) when administered in Combination with Calcineurin Inhibitors in Renal Transplant Recipients Experiencing Gastrointestinal Intolerance (myGAIN) (CERL080AUS51) |
Dr. Thistlethwaite's lab |
| James Williams | Pyrimidine Levels in Patients with Kidney Disease |
Urology
Visit the Urology research page for more information.
| Investigator | Title | Related Links |
|---|---|---|
| Gregory Bales | Prospective Evaluation of Intravesical Botulinum - A Toxin Injection in Patients with Overactive Bladder Symptoms A Pre-Market Study of the AMS Transobturator Male Sling System for the Treatment of Male Stress Urinary Incontinence Urethroplasty - Patient Outcomes |
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| Clare Close | Pediatric Outcomes of Fetal Sonographyically Evident Renal Pyelectasis (SERP) Retrospective Evalaution of Dysfunctional Elimination in Pediatric Monosymptomatic Enuresis |
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| Glenn Gerber | A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy and Safety of Dutasteride 0.5 mg Administered Orally Once Daily for Four Years to Reduce the Rise of Biopsy-Detectable Prostate Cancer | |
| Arieh Shalhav | Minimally-Invasive Radical Prostatectomy Laparoscopic Pyeloplasty - The University of Chicago Experience |
Dr. Shalhav in "Spark Discovery, Illuminate Life" |
| Gary Steinberg | Open-Label, Multi-Center Study of the Efficacy and Safety of MCC in the Treatment of Patients with Non-Muscle Invasive (Superficial) Bladder Cancer at High Risk of Progression and Who are Refractory to BCG A Multicenter, Randomized Placebo-Controlled, Double Blind, Phase 3 Trial of Single-Dose Intravesical Eoquin as a Surgical Aduvant Instilled in the Early Postoperative Period in Patients Undergoing Transurethral Resection for Noninvasive Bladder Cancer Detection of Bladder Cancer by Microsatellite Analysis (MSA) of Urinary Sediment: Multi-Institutional Study |
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| Gregory Zagaja | Phase II, Randomized, Doubld Blind, Multi-Centered Study of Polyphenon E in Men with High Grade Prostatic Intraepithelial Neoplasia (HGPIN) Quality of Life After Radical Prostatectomy Reevaluation of Prostate Biopsy Specimens May Avoid Need for Re-Biopsy in Patients with High Grade PIN |
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| Kevin Zorn | Sexual Function after a Robotic Assisted Laparoscopic Prostatectomy: Effect of Race on Recovery Outcomes |
Vascular Surgery and Endovascular Therapy
Visit the Vascular Surgery research page for more information.
| Investigator | Title | Related Links |
|---|---|---|
| Hisham Bassiouny | Hemodynamic Therapy in Peripheral Arterial Disease Thrombectomy of Femoral-Popliteal Bypass Grafts Comparing Open Versus Endovascular Interventions for Mesenteric Ischemia |
Dr. Bassiouny's lab |
| Tina Desai | Clinical Evaluation of Efficacy and Safety of Fibrin Sealant VH S/D 500 S-APR For Hemostasis in Subjects Undergoing Vascular Surgery University of Chicago Vascular Experience Screening Protocol Stenting and Angioplasty with Protection in Patients at High-Risk for Endarterectomy |
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| Christopher Skelly | Review of Carotid Artery Disease | Dr. Skelly's lab |
Ophthalmology & Visual Sciences
Visit the Ophthalmology research page for more information.
| Investigator | Title | Related Links |
|---|---|---|
| Rima McLeod | Phase II Randomized Study of Pyrimethamine, Sulfadiazine, and Leucovorin Calcium for Congenital Toxoplasmosis |
