The Department of Surgery

The University of Chicago

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Robert Naclerio, MD

Professor of Surgery
Chief, Section of Otolaryngology-Head & Neck Surgery

The University of Chicago
5841 S. Maryland Avenue, MC1035
Chicago, IL 60637
Phone: (773) 702-1865
Fax: (773) 702-9813

Robert Naclerio, MD, is an accomplished clinician-scientist.  In 1980, Dr. Naclerio suspended his clinical training in Otolaryngology at the Baylor College of Medicine to learn more about research in the field of clinical immunology. He participated in a two-year NIH-sponsored fellowship under the direction of Lawrence Lichtenstein, MD, PhD, and Philip Norman, MD.

After completing his fellowship, Dr. Naclerio completed his final year of residency. He then joined the faculty of the Johns Hopkins School of Medicine.  There, his interest in basic research into mechanisms of allergic rhinitis and related diseases paralleled his clinical interests in rhinosinusitis.  These interests have continued at The University of Chicago since 1994.

Dr. Naclerio’s research focuses on using human subjects and mice to study basic mechanisms of allergic and nonallergic diseases of the nose and sinuses. He has attempted to understand how basic principles arising from single-cell studies and animals apply to the complex microenvironment that exists in the human nose.  

Current interests focus on:
  • Understanding the effect of inflammation on the ability of the nose to warm and humidify air
  • The role of allergy in worsening bacterial sinusitis in a mouse model
  • Understanding the effect of genetic predisposition on development of chronic sinusitis
  • Understanding how intranasal steroids reduce ocular symptoms of allergic rhinitis
  • Investigating the effect of treatment on the mechanisms underlying allergic rhinitis.
Current ongoing clinical trials include the use of CO2, the combination of an intranasal steroid and a topical decongestant, and the combination of montelukast and an intranasal steroid in the treatment of allergic rhinitis.  In collaboration with investigators from the law and business schools, Dr. Naclerio's lab is evaluating the neural-immunological impact of commercials on the allergic reaction.