The University of Chicago Comer Children's Hospital is home to the busiest Extracorporeal Life Support (ECMO) Program in Chicago. Our staff consists of a large team of perfusionists who are experts in prolonged cardiopulmonary bypass, and a team of ECMO specialists, both nurses and respiratory therapists who have been through rigorous training to manage the pump. We can provide extracorporeal life support to children of all ages as well as adults. Nearly 40 patients are supported each year with an overall survival rate of 75% and a greater than 90% survival for neonates wit respiratory failure. Approximately 50% of our runs are for support of cardiac failure in children with congenital heart defects. We look forward to continuing to grow our program and to improve the delivery of care to these very fragile patients.