Venous disease occurs most frequently in the lower extremities. The most common disorders are inflammation of the vein, deep vein thrombosis and chronic venous insufficiency--including varicose veins. Deep vein thrombosis is often treated with an anticoagulation agent administered by a vascular surgeon. Chronic venous insufficiency may be treated by vein valve reconstruction. At the University of Chicago Medical Center, varicose veins are often treated medically with special stockings or injected medications. Such injection of sclerosing medication, or sclerotherapy, can be further optimized by using ultrasound localization with our state-of-the-art vascular lab facilities. In rare cases, varicose veins may be treated by surgically removing the vein.