Dr. Pinto's research program has three major thematic goals:
1) To understand the effect of aging on sinonasal and sensory disorders
2) To determine how genetics, the environment, and social context (and their interaction) modulate susceptibility to these conditions
3) To use this information to develop and test novel treatments for these and other common conditions of the ear, nose, and throat
He utilizes tools from the fields of demography, genetic epidemiology, genomics, public health and sociology to accomplish these goals. Dr. Pinto's research is funded by the National Institute on Aging and the National Institute of Allergy and Infectious Disease.
Epidemiology of Presbyosmia (Age-Related Olfactory Decline)
We are exploiting data from the National Social Life, Health, and Aging Project (NSHAP) (led by Linda Waite in Sociology), to study the demographic and other non-genetic factors that are associated with olfactory decline in aging. We have identified race as a key factor that is independently associated with olfactory function and demonstrated that anosmia predicts five year all cause mortality in US adults, providing some the first nationally representative data on this condition. We are also examining the rich array of health and social measures available in NSHAP, including state of the art biomeasures to determine underlying biological mechanisms and environmental determinants. Additional members of the Olfactory Research Group (the ORG) include Martha McClintock in Psychology and William Dale in Geriatric and Palliative Medicine, along with statisticians Kristin Wroblewski and Philip Schumm in Public Health Studies.
Genetics of Presbyosmia
?We are employing genome wide association studies in a founder population to identify genetic variation that underlies age-related olfactory loss using quantitative trait loci mapping in collaboration with Carole Ober in Human Genetics. We published the first successful linkage study for an olfactory trait in humans and are pursuing other collaborations (David Bennett, Rush University) to identify genetic contributions to this important disorder.
Genetics of Chronic Rhinosinusitis
We are performing state of the art genetic, epigenetic, and genomic studies of CRS as part of the Chronic Rhinosinusitis Integrated Studies Program, a U19 award from the National Institute of Allergy and Infectious Disease in collaboration with Northwestern University (Robert Schleimer) and Johns Hopkins University/Geisinger Health System (Brian Schwartz). The project at The University of Chicago, in partnership with Carole Ober, focuses on genetic variation in pathogen response. Our project is the only National Institutes of Health-funded project on the genetics of this disorder.
The Upper Airway Microbiome
We have shown that the microbial ecology in the middle meatus of the sinuses is altered in allergic subjects, potentially predisposing to disease. We have several ongoing investigations into how the sinonasal microbiome predicts physiological changes in both the upper and lower airway, as well as factors that affect its composition and function. Collaborating on these projects are Robert Naclerio and Fuad Baroody in OHNS, along with Carole Ober and Yoav Gilad in Human Genetics.
Rhinology Clinical Trials and Translational Research
The Nasal Physiology Laboratory, a joint endeavor with Robert Naclerio and Fuad Baroody, runs ongoing clinical trials and translational studies of conditions such as allergic and non-allergic rhinitis, chronic rhinosinusitis, nasal polyposis, and other common conditions. Call 773-702-5889 for details on our current projects.
University of Chicago
Research Fellowship - Section of OHNS, Department of Human Genetics, Section of Pulmonary/Critical Care Medicine
University of Chicago
Residency - Section of OHNS
University of Chicago
Internship - Department of Surgery
Stanford University School of Medicine
Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities.
Mainland JD, Barlow LA, Munger SD, Millar SE, Vergara MN, Jiang P, Schwob JE, Goldstein BJ, Boye SE, Martens JR, Leopold DA, Bartoshuk LM, Doty RL, Hummel T, Pinto JM, Trimmer C, Kelly C, Pribitkin EA, Reed DR. Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities. Chem Senses. 2020 Oct 09; 45(7):493-502.
Self-Reported Versus Objectively Assessed Olfaction and Parkinson's Disease Risk.
Cao Z, Luo Z, Huang X, Pinto JM, Simonsick EM, Shiroma EJ, Chen H. Self-Reported Versus Objectively Assessed Olfaction and Parkinson's Disease Risk. J Parkinsons Dis. 2020 Sep 09.
Identification of Viruses in Patients With Postviral Olfactory Dysfunction by Multiplex Reverse-Transcription Polymerase Chain Reaction.
Tian J, Pinto JM, Li L, Zhang S, Sun Z, Wei Y. Identification of Viruses in Patients With Postviral Olfactory Dysfunction by Multiplex Reverse-Transcription Polymerase Chain Reaction. Laryngoscope. 2020 Aug 12.
Hearing Impairment and Loneliness in Older Adults in the United States.
Huang AR, Deal JA, Rebok GW, Pinto JM, Waite L, Lin FR. Hearing Impairment and Loneliness in Older Adults in the United States. J Appl Gerontol. 2020 Aug 04; 733464820944082.
The Treatment Paradigm of Chronic Rhinosinusitis with Nasal Polyps in the COVD-19 Era.
Roland LT, Pinto JM, Naclerio RM. The Treatment Paradigm of Chronic Rhinosinusitis with Nasal Polyps in the COVD-19 Era. J Allergy Clin Immunol Pract. 2020 Sep; 8(8):2492-2494.
IL-1Rahigh-IL-4low-IL-13low: A Novel Plasma Cytokine Signature Associated with Olfactory Dysfunction in Older US Adults.
Darnell EP, Wroblewski KE, Pagel KL, Kern DW, McClintock MK, Pinto JM. IL-1Rahigh-IL-4low-IL-13low: A Novel Plasma Cytokine Signature Associated with Olfactory Dysfunction in Older US Adults. Chem Senses. 2020 May 29; 45(5):407-414.
Odor Sensitivity Versus Odor Identification in Older US Adults: Associations With Cognition, Age, Gender, and Race.
Xu L, Liu J, Wroblewski KE, McClintock MK, Pinto JM. Odor Sensitivity Versus Odor Identification in Older US Adults: Associations With Cognition, Age, Gender, and Race. Chem Senses. 2020 May 21; 45(4):321-330.
Tissue Specific Fate of Nanomaterials by Advanced Analytical Imaging Techniques - A Review.
Graham UM, Dozier AK, Oberdörster G, Yokel RA, Molina R, Brain JD, Pinto JM, Weuve J, Bennett DA. Tissue Specific Fate of Nanomaterials by Advanced Analytical Imaging Techniques - A Review. Chem Res Toxicol. 2020 May 18; 33(5):1145-1162.
Olfaction and changes in body composition in a large cohort of older US adults.
Purdy F, Luo Z, Gardiner JC, Pinto JM, Shiroma EJ, Simonsick EM, Harris TB, Chen H. Olfaction and changes in body composition in a large cohort of older US adults. J Gerontol A Biol Sci Med Sci. 2020 Apr 08.
Clinical Research Needs for the Management of Chronic Rhinosinusitis with Nasal Polyps in the New Era of Biologics: A National Institute of Allergy and Infectious Diseases Workshop.
Naclerio R, Baroody F, Bachert C, Bleier B, Borish L, Brittain E, Chupp G, Fisher A, Fokkens W, Gevaert P, Kennedy D, Kim J, Laidlaw TM, Lee JJ, Piccirillo JF, Pinto JM, Roland LT, Schleimer RP, Schlosser RJ, Schwaninger JM, Smith TL, Tan BK, Tan M, Toskala E, Wenzel S, Togias A. Clinical Research Needs for the Management of Chronic Rhinosinusitis with Nasal Polyps in the New Era of Biologics: A National Institute of Allergy and Infectious Diseases Workshop. J Allergy Clin Immunol Pract. 2020 May; 8(5):1532-1549.e1.